Detalhe da pesquisa
1.
Analysis of the Bile Acid Composition in a Fibroblast Growth Factor 19-Expressing Liver-Humanized Mouse Model and Its Use for CYP3A4-Mediated Drug-Drug Interaction Studies.
Drug Metab Dispos
; 51(10): 1391-1402, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37524541
2.
Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions.
Biopharm Drug Dispos
; 41(1-2): 72-88, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31925778
3.
Metabolism of Scoparone in Experimental Animals and Humans.
Planta Med
; 85(6): 453-464, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30736072
4.
Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling.
Mol Pharm
; 13(4): 1358-65, 2016 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26950248
5.
Quantitative ADME proteomics - CYP and UGT enzymes in the Beagle dog liver and intestine.
Pharm Res
; 32(1): 74-90, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25033762
6.
In vitro to in vivo extrapolation and physiologically based modeling of cytochrome P450 mediated metabolism in beagle dog gut wall and liver.
Mol Pharm
; 10(4): 1388-99, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23438212
7.
Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.
Pharm Res
; 29(7): 1832-42, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22354837
8.
PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates.
Pharmaceutics
; 13(9)2021 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34575401
9.
Effects of experimental setup on the apparent concentration dependency of active efflux transport in in vitro cell permeation experiments.
Mol Pharm
; 7(2): 605-17, 2010 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20163161
10.
In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs.
Eur J Pharm Sci
; 141: 105118, 2020 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31669387
11.
Kinetics of cellular retention during Caco-2 permeation experiments: role of lysosomal sequestration and impact on permeability estimates.
J Pharmacol Exp Ther
; 328(3): 882-92, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19088303
12.
Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies.
Clin Pharmacokinet
; 58(6): 727-746, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30729397
13.
Protein concentration and pH affect the apparent P-glycoprotein-ATPase activation kinetics.
Int J Pharm
; 346(1-2): 169-72, 2008 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17624702
14.
Dissolution behavior of co-amorphous amino acid-indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin.
Eur J Pharm Biopharm
; 112: 85-95, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27888143
15.
The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development.
Proteomics Clin Appl
; 9(7-8): 732-44, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25676057
16.
Fentanyl Pharmacokinetics in Pregnant Sheep after Intravenous and Transdermal Administration to the Ewe.
Basic Clin Pharmacol Toxicol
; 117(3): 156-63, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25626156
17.
Applications of a 7-day Caco-2 cell model in drug discovery and development.
Eur J Pharm Sci
; 56: 120-30, 2014 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24576578
18.
In vitro methods to study the interplay of drug metabolism and efflux in the intestine.
Curr Drug Metab
; 14(1): 102-11, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22497570
19.
Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - an evaluation and case study using GastroPlus.
Eur J Pharm Sci
; 47(2): 375-86, 2012 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22759901
20.
Modelling of drug disposition kinetics in in vitro intestinal absorption cell models.
Basic Clin Pharmacol Toxicol
; 106(3): 180-8, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20030630